(S)-tert-butyl 16-(3-((4-cyclobutoxy-2-(4-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)phenyl)-4,7,10,13-tetraoxahexadecan-1-oate → (S)-2-(2-(3-(2,5,8,11,14,17,20,23,26-nonaoxaheptacosyl)benzamido)-5-cyclobutoxyphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)isonicotinamide

HRID 625469Notes

Reaction equation

HRID 625469 reaction equation
[CH:1]1([O:5][C:6]2[CH:11]=[CH:10][C:9]([NH:12]C(C3C=C(CCCOCCOCCOCCOCCC(OC(C)(C)C)=O)C=CC=3)=O)=[C:8]([C:43]3[CH:48]=[C:47]([C:49](=[O:61])[NH:50][C@@H:51]4[C:60]5[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=5)[CH2:54][CH2:53][CH2:52]4)[CH:46]=[CH:45][N:44]=3)[CH:7]=2)[CH2:4][CH2:3][CH2:2]1.[CH2:62]([C:89]1[CH:90]=[C:91]([CH:95]=[CH:96][CH:97]=1)[C:92]([OH:94])=O)[O:63][CH2:64][CH2:65][O:66][CH2:67][CH2:68][O:69][CH2:70][CH2:71][O:72][CH2:73][CH2:74][O:75][CH2:76][CH2:77][O:78][CH2:79][CH2:80][O:81][CH2:82][CH2:83][O:84][CH2:85][CH2:86][O:87][CH3:88]>>[CH2:62]([C:89]1[CH:90]=[C:91]([CH:95]=[CH:96][CH:97]=1)[C:92]([NH:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH:1]2[CH2:4][CH2:3][CH2:2]2)=[CH:7][C:8]=1[C:43]1[CH:48]=[C:47]([CH:46]=[CH:45][N:44]=1)[C:49]([NH:50][C@@H:51]1[C:60]2[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=2)[CH2:54][CH2:53][CH2:52]1)=[O:61])=[O:94])[O:63][CH2:64][CH2:65][O:66][CH2:67][CH2:68][O:69][CH2:70][CH2:71][O:72][CH2:73][CH2:74][O:75][CH2:76][CH2:77][O:78][CH2:79][CH2:80][O:81][CH2:82][CH2:83][O:84][CH2:85][CH2:86][O:87][CH3:88]

Participants

3

Reactant 2

HCID 66586867(S)-tert-butyl 16-(3-((4-cyclobutoxy-2-(4-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)phenyl)-4,7,10,13-tetraoxahexadecan-1-oateHCID 665875753-(2,5,8,11,14,17,20,23,26-Nonaoxaheptacosyl)benzoic acid

Product 1

HCID 86705979(S)-2-(2-(3-(2,5,8,11,14,17,20,23,26-nonaoxaheptacosyl)benzamido)-5-cyclobutoxyphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)isonicotinamide

Procedure

This compound was prepared according to the procedure described for the synthesis of (S)-tert-butyl 16-(3-((4-cyclobutoxy-2-(4-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)phenyl)-4,7,10,13-tetraoxahexadecan-1-oate Example 284, using intermediate 3-(2,5,8,11,14,17,20,23,26-nonaoxaheptacosyl)benzoic acid in place of 3-(2,2-dimethyl-4-oxo-3,7,10,13,16-pentaoxanonadecan-19-yl)benzoic acid. MS (ES, m/z): 914.6 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-836630d488e447f88e55029e376426c0
Source dataset
uspto-grants-2016_04
Patent number
US09301951B2

Reaction notes

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