(2-Methoxyethyl)(methyl)amine → HCID 66587989, compound

HRID 625471Notes

Reaction equation

HRID 625471 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]([CH3:59])[CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24](=[O:58])[NH:25][C:26]3[CH:31]=[CH:30][C:29]([N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)=[CH:28][C:27]=3[C:38]3[CH:43]=[C:42]([C:44](=[O:57])[NH:45][CH2:46][C:47]4[CH:52]=[CH:51][CH:50]=[C:49]([C:53]([F:56])([F:55])[F:54])[CH:48]=4)[CH:41]=[CH:40][N:39]=3)[CH:19]=2)[CH2:10][CH2:9]1)=[O:7].[CH3:60]OCCNC>>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH3:60])[C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][N:16]([CH3:59])[CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24](=[O:58])[NH:25][C:26]3[CH:31]=[CH:30][C:29]([N:32]4[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]4)=[CH:28][C:27]=3[C:38]3[CH:43]=[C:42]([C:44](=[O:57])[NH:45][CH2:46][C:47]4[CH:52]=[CH:51][CH:50]=[C:49]([C:53]([F:54])([F:55])[F:56])[CH:48]=4)[CH:41]=[CH:40][N:39]=3)[CH:19]=2)[CH2:12][CH2:13]1)=[O:7]

Participants

3

Reactant 2

HCID 300977(2-Methoxyethyl)(methyl)amineHCID 66586991HCID 66586991, compound

Product 1

HCID 66587989HCID 66587989, compound

Procedure

This compound was prepared according to the procedure described for the synthesis of N-(2-methoxyethyl)-4-(2-(methyl(3-(4-(piperidin-1-yl)-2-(4-(3-(trifluoromethyl)benzylcarbamoyl)pyridin-2-yl)phenylcarbamoyl)benzyl)amino)ethyl)piperazine-1-carboxamide Example 208 substituting 2-methoxy-N-methylethanamine in place of 2-methoxyethanamine. LC-MS (ES, m/z): 829 [M+H]+ H-NMR (300 MHz, DMSO, ppm): 12.31 (s, 1H), 9.56 (t, J=3.6 Hz, 1H), 8.93 (d, J=6 Hz, 1H), 8.31 (d, J=6 Hz, 2H), 8.04 (s, 1H), 7.94 (d, J=9 Hz, 1H), 7.84-7.86 (m, 1H), 7.56-7.71 (m, 7H), 7.30 (d, J=9 Hz, 1H), 4.63 (d, J=3 Hz, 2H), 4.26 (s, 2H), 3.45 (t, J=6.6 Hz, 2H), 3.23-3.32 (m, 16H), 3.17 (s, 1H), 3.00 (s, 4H), 2.80 (s, 3H), 2.63 (s, 3H), 1.60-1.74 (m, 6H).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5137a40e21be46f882a747f4ff752fac
Source dataset
uspto-grants-2016_04
Patent number
US09301951B2

Reaction notes

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