Formaldehyde → HCID 66559267, compound

Participants

Reaction Conditions

Reaction Steps

N-[4-{[3,3,3-Trifluoro-2-hydroxy-2-(3,4,5-trichlorophenyl)propyl]amino}-2-(trifluoromethyl)benzyl]propane amide (250 mg) and formaldehyde (70 mg) were added to toluene (20 mL), and stirred at 90° C. for 5 hours. After the reaction, the solvent was distilled off under reduced pressure and the residues were purified by silica-gel column chromatography to give N-{4-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-1,3-oxazolidin-3-yl]-2-(trifluoromethyl)benzyl}propane amide (100 mg).

Provenance & Evidence