4-Benzyloxy-3-fluorophenylboronic Acid → (1S,2S)-2-{4-[(R)-4-(4-Benzyloxy-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-phenyl}-cyclopropanecarboxylic acid ethyl ester

Participants

Reaction Steps

The title compound is prepared from (1S,2S)-2-[4-((R)-7-fluoro-4-hydroxy-indan-1-yloxy)-phenyl]-cyclopropanecarboxylic acid ethyl ester (Intermediate 5, 0.8 g, 2.2 mmol) and 4-benzyloxy-3-fluorophenylboronic acid (2.21 g, 9.0 mmol) in a manner analogous to that described for Intermediate 6 (Yield 0.8 g). LC (METHOD 6): tR=0.96 min; Mass spectrum (ES+): m/z=557 [M+H]+.

Provenance & Evidence