(S)-4-bromo-7-fluoro-2,3-dihydro-1H-inden-1-ol → (S)-4-bromo-1-hydroxy-indan-5-carbonitrile

関与物質

反応手順

The compound is synthesized from 4-bromo-1-oxo-indan-5-carbonitrile (2.20 g, 5.1 mmol) in analogy to the preparation of intermediate 2 (Yield 1.30 g). GC (METHOD 1): tR=11.59 min; Mass spectrum (EI+): m/z=237 [M]+, e.e. 98% by chiral HPLC (Column: Daicel Chiralpak OJ-H, 4.6×250 mm, 5 μm Mobile phase: hexane:ethanol 95:5, 1 mL/min, 25° C.) tR=37.52 min.

情報源と証拠