HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → HCID 12551991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Indanone, 4-bromo- | HCID 98713 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 12551991 | HCID 12551991 | — |
Reaction Steps
4-Bromo-1-indanone (0.30 g), thiophenol (0.15 mL), tris(dibenzylideneacetone)palladium(0) (0.13 g), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (0.082 g) and N,N-diisopropylethylamine (0.98 mL) are stirred in dioxane (1 mL) for 2 hours under microwave irradiation at 120° C. After removal of the solvent under vacuum the residue is purified by column chromatography (silica gel, cyclohexane:ethyl acetate 6:4) to give the desired material (0.34 g). LC (METHOD 5): tR=1.28 min; Mass spectrum: m/z=241 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09308194B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-2d7233cae0fb4064bc5086e63433b67d |
| Source note | uspto-grants-2016_04 |