Formic Acid → HCID 118093718, compound

Participants

Reaction Conditions

Reaction Steps

Under nitrogen a solution of the material from Step 2 (0.39 g) in CH2Cl2 (10 mL) is added dropwise to a stirred mixture of formic acid (0.20 mL) and triethylamine (0.61 mL) with cooling in an ice-bath. Chloro([1S,2S)-(−)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido)(mesitylene)ruthenium(II) (26 mg) is added and the reaction mixture stirred at 0° C. for 3 hours. Water is added and the resulting mixture extracted twice with ethyl acetate. The combined organic layers are washed (saturated aqueous NaHCO3), dried and purified by column chromatography (silica gel, cyclohexane:ethyl acetate gradient 100:0 to 50:50), to obtain the desired material (0.39 g). LC (METHOD 14): tR=0.83 min; Mass spectrum: m/z=257 [M+H−H2O]+.

Provenance & Evidence