4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline → HCID 178517771, compound

HRID 625739Notes

Reaction equation

HRID 625739 reaction equation
ClC1C2C(=CC(C)=CC=2)N=C(C(F)(F)C2C=CC(F)=CC=2)N=1.[F:23][C:24]([F:44])([C:37]1[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=1)[C:25]1[N:34]=[C:33]([OH:35])[C:32]2[C:27](=[CH:28][C:29](C)=[CH:30][CH:31]=2)[N:26]=1>>[F:44][C:24]([F:23])([C:37]1[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=1)[C:25]1[N:34]=[C:33]([OH:35])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:26]=1

Participants

3

Reactant 2

HCID 729429274-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazolineHCID 178422977HCID 178422977, compound

Product 1

HCID 178517771HCID 178517771, compoundYield 95%

Procedure

4-Chloro-2-(difluoro(4-fluorophenyl)methyl)quinazoline was obtained according to the procedure described in Example 26 for preparation of 4-chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline, substituting 2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazolin-4-ol in Example 26 with 2-(difluoro(4-fluorophenyl)methyl)quinazolin-4-ol (95% yield). LC-MS (ESI) m/z 308 (M+H)+.

Sources & evidence

ORD record
ord-1c27978bcce04d5bbfdfac203b935add
Source dataset
uspto-grants-2016_04
Patent number
US09308207B2

Reaction notes

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