HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-4-(trifluoromethyl)benzamide → 2-Amino-4-(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-4-(trifluoromethyl)benzamide | HCID 2775779 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-4-(trifluoromethyl)benzamide | HCID 69739 | 96.4% |
Reaction Steps
To 2-nitro-4-(trifluoromethyl)benzamide (1000 mg, 4.27 mmol), in MeOH (15 mL) was added palladium hydroxide 20% by weight (230 mg) and the mixture was stirred at rt overnight. The reaction mixture was filtered through Celite washing with MeOH. The crude mixture was concentrated in vacuo to afford 2-amino-4-(trifluoromethyl)benzamide (840 mg, 96%). LC-MS (ESI) m/z 205 (M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09308207B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-e689978c0be84c56b986bd2ae3fe9c8b |
| Source note | uspto-grants-2016_04 |