4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline → 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline

HRID 625768Notes

Reaction equation

HRID 625768 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8](C)=[CH:9][CH:10]=2)[N:5]=[C:4]([C:13]([F:22])([F:21])[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[N:3]=1.FC(F)(C1C=CC(F)=CC=1)C1N=[C:33]([OH:35])C2C(=CC(C)=CC=2)N=1.FC(F)(C1C=CC(F)=CC=1)C1N=C(O)C2C(=CC(OC)=CC=2)N=1>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:35][CH3:33])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:13]([F:22])([F:21])[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[N:3]=1

Participants

4

Reactant 3

HCID 729429274-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazolineHCID 178422977HCID 178422977, compoundHCID 178487748HCID 178487748, compound

Product 1

HCID 866490574-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline

Procedure

4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline was obtained according to the procedure described in Example 26 for synthesis of 4-chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline, substituting 2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazolin-4-ol in Example 26 with 2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazolin-4-ol. 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline was isolated as a light yellow solid (0.290 g, 89%). LC-MS (ESI) m/z 339 (M+H)+.

Sources & evidence

ORD record
ord-7abfecaa7555480b9d53626381cee1a5
Source dataset
uspto-grants-2016_04
Patent number
US09308207B2

Reaction notes

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