HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methoxybenzamide → 2-(2,2-Difluoro-2-(4-fluorophenyl)acetamido)-3-fluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methoxybenzamide | HCID 14023002 | — |
| Reactant | 2-Amino-3-fluorobenzamide | HCID 15256791 | — |
| Reactant | 2-(2,2-Difluoro-2-(4-fluorophenyl)acetamido)-4-methoxybenzamide | HCID 66611437 | — |
| Product | 2-(2,2-Difluoro-2-(4-fluorophenyl)acetamido)-3-fluorobenzamide | HCID 66609613 | — |
Reaction Steps
2-(2,2-Difluoro-2-(4-fluorophenyl)acetamido)-3-fluorobenzamide was prepared according to the procedure described in Example 32 for preparation of 2-(2,2-difluoro-2-(4-fluorophenyl)acetamido)-4-methoxybenzamide, substituting 2-amino-4-methoxybenzamide in Example 32 with 2-amino-3-fluorobenzamide. The product was purified on silica gel column using DCM/MeOH as eluent (20%); LC-MS (ESI) m/z 327 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09308207B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-eba581a831c54f3abf5314f30eb5dac7 |
| Source note | uspto-grants-2016_04 |