HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → p-SCN-Benzyl-dtpa
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 2-[[3-(4-Aminophenyl)-2-[bis(carboxymethyl)amino]propyl]-[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid | HCID 131596 | — |
| Solvent | Water | HCID 962 | — |
| Product | p-SCN-Benzyl-dtpa | HCID 10143607 | 99% |
Reaction Steps
To a solution of 6a (10 mg, 0.0155 mmol) in water (100 μL) was added dropwise 1M thiophosgene in CHCl3 (18.6 μL, 0.0186 mmol). The resulting mixture was stirred at room temperature for 3 h. The aqueous layer was concentrated in vacuo to provide pure 7a (10 mg, 99%) as a light yellowish solid. 1H NMR (MeOD, 300 MHz) δ 2.50-4.55 (m, 24H), 7.10-70 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446995B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-bc6d311a6d1e4d67abb1e9e44d62a533 |
| Source note | uspto-grants-2016_09 |