反应详情

温度

55 °C

A suspension of 135 mg (0.27 mmol) of (R,R)-arformoterol tartrate Form A and 7.5 mL of methanol was heated to the reflux temperature of the solvent for 10 min. Then, the solution obtained was allowed to cool to about 50-60° C., followed by addition of 19 mL of acetonitrile at the same temperature. Afterwards, the solution was cooled to room temperature and stirred for 1 hour. The product was collected by filtration, washed with acetonitrile and dried under vacuum (2-3 mbar, equivalent to 1.5-2.25 mm Hg) at 25° C. for 1 hour to provide acetonitrile solvate of (R,R)-Formoterol-L-tartrate, which contained about 2.5% (w/w) of acetonitrile, as determined by 1H-NMR analysis.

1. temperaturewas heated to the reflux temperature of the solvent for 10 min
2. customThen, the solution obtained
3. temperatureAfterwards, the solution was cooled to room temperature
4. filtrationThe product was collected by filtration
5. washwashed with acetonitrile
6. customdried under vacuum (2-3 mbar, equivalent to 1.5-2.25 mm Hg) at 25° C. for 1 hour