反应详情

温度

0 °C

150 mg (0.46 mmol) of N-(tert-butoxycarbonyl)-2,2-difluoro-2-(3-butoxyphenyl)ethylamine are dissolved in dry DMF (2.5 mL) and the solution was cooled to 0° C. NaH (60% in mineral oil; 22 mg; 0.55 mmol) is added and the reaction mixture stirred for 10 minutes at 0° C. and for further 10 minutes at room temperature. The reaction mixture is cooled again at 0° C., then N,N-dimethylchloroacetamide (73 mg; 0.60 mmol) is added and stirring is continued for 24 hours at room temperature. The reaction is quenched with water, extracted three times with EtAc, washed with brine. The organic phases are dried over anhydrous Na2SO4, filtered and evaporated. The residue is flash-chromatographed on silica gel (eluant: DCM/EtAc, from 98/2 to 95/5). 2-[N′-(tert-butoxycarbonyl)-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethyl-acetamide (165 mg; 87%) is obtained as a white solid.

1. temperatureThe reaction mixture is cooled again at 0° C.
2. stirringstirring
3. waitis continued for 24 hours at room temperature
4. customThe reaction is quenched with water
5. extractionextracted three times with EtAc
6. washwashed with brine
7. dry with materialThe organic phases are dried over anhydrous Na2SO4
8. filtrationfiltered
9. customevaporated
10. customThe residue is flash-chromatographed on silica gel (eluant: DCM/EtAc, from 98/2 to 95/5)