HCID 70983531, compound → HCID 70982799, compound

Participants

Reaction Conditions

Reaction Steps

0.11 mmol of ethyl 1-benzyl-8-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carboxylate were dissolved in a solution of potassium hydroxide in ethanol (20%). The solution was heated in the microwave at 100° C. for 3 h. The mixture was diluted with brine and extracted with ethyl acetate (3×). The combined organic layers were concentrated in vacuo to give 96 mg of crude material that was purified by flash chromatography to yield 37 mg of N-(2-(1-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide (77%).

Provenance & Evidence