HCID 67406794, compound → HCID 67406460, compound

Participants

Reaction Steps

To the above mixture of 2-(biphenyl-3-yl)-3-bromo-5,6-dimethoxypyridine and 3-(biphenyl-3-yl)-2-bromo-5,6-dimethoxypyridine (50 mg, 0.135 mmol) were added, under argon, Zn(CN)2 (32 mg, 0.27 mmol), Zn powder (0.9 mg, 0.014 mmol), Pd2(dba)3 (12.4 mg, 0.014 mmol), DPPF (15 mg, 0.027 mmol), DMA (2 mL) and stirred at 120° C. for 3.5 h. Cooled to room temperature and filtered. Purification by preparative HPLC (10->85% CH3CN/H2O over 20 min, 0.05% added TFA) afforded 17 mg (39%) of 2-(biphenyl-3-yl)-5,6-dimethoxypyridine-3-carbonitrile as a tan solid. LC/MS (M+H)+ 317.2.

Provenance & Evidence