Benzyl Bromide → HCID 67420240, compound

Participants

Reaction Steps

To a suspension of 5-biphenyl-3-yl-4-fluoro-3-hydroxypyridin-2(1H)-one (60 mg, 0.213 mmol) was added 1 N aqueous NaOH solution (0.235 mL, 0.235 mmol) and the resulting mixture was sonicated to make a clear solution. To this mixture was added a solution of benzyl bromide (37 mg, 0.213 mmol) in MeOH (0.3 mL) dropwise, stirred overnight at room temperature and then concentrated. Purification by preparative HPLC (10-70% CH3CN/H2O over 20 min, 0.05% added TFA) afforded 25 mg (32%) of 3-(benzyloxy)-5-(biphenyl-3-yl)-4-fluoropyridin-2(1H)-one as a white solid. LC/MS (M+H)+ 372.2.

Provenance & Evidence