Boron tribromide → HCID 59191211, compound

Participants

Reaction Steps

To a solution of 2-fluoro-6-(2-methoxy-4-propylphenoxy)pyridine (1.7 mmol; 449 mg) under argon, in dichloromethane (1.5 mL), cooled to −78° C., was added BBr3 (17 mmol; 1M in CH2Cl2; 17 mL). The reaction mixture was allowed to stir overnight, with gradual heating to room temperature. At −20° C., the reaction was hydrolysed with saturated NH4Cl (3 mL), extracted with ethyl acetate (3*10 mL). Combined organic phases were dried over MgSO4, concentrated in vacuo. The residue was chromatographed on silica gel (gradient cyclohexane/dichloromethane) to give the desired product as a white solid (160 mg; 0.65 mmol; 38%).

Provenance & Evidence