HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-{bicyclo[1.1.1]pentan-1-yl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Bicyclo(1.1.1)pentan-1-amine | HCID 11469065 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-{bicyclo[1.1.1]pentan-1-yl}acetamide | HCID 86287956 | — |
Reaction Steps
The commercially available bicyclo[1.1.1]pentan-1-amine can be coupled with an appropriate carboxylic acid or acid chloride, such as acetyl chloride in the presence of base (for example, K2CO3, Na2CO3, NaHCO3, TEA, pyridine, and the like) to give N-(bicyclo[1.1.1]pentan-1-yl)acetamide (4) (Scheme 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447025B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-7c655318d8064f35bdd84038479cdbe8 |
| Source note | uspto-grants-2016_09 |