反应详情

温度

80 °C

To 2-(4-ethyl-2-methoxyphenoxy)-6-fluoropyridine (94 mg; 0.32 mmol), under argon, was added butylamine (0.5 mL). The reaction was heated to 80° C. for 18 hours. The mixture was concentrated in vacuo. After quenching with saturated NaHCO3 (10 mL), extractions with dichloromethane (3*5 mL), the organic phase was dried over NaSO4, and concentrated in vacuo to give the title compound as a light brown oil used without further purification (87 mg; 0.29 mmol; 89%).

1. concentrationThe mixture was concentrated in vacuo
2. customAfter quenching with saturated NaHCO3 (10 mL), extractions with dichloromethane (3*5 mL)
3. dry with materialthe organic phase was dried over NaSO4
4. concentrationconcentrated in vacuo