Lithium Hydroxide → HCID 59191230, compound

Participants

Reaction Steps

To a solution of 5-(2-hydroxy-4-propylphenoxy)pyridin-2-ol (0.08 mmol; 20 mg) under argon, in anhydrous DMF (0.5 mL) cooled to 0° C., were added LiOH (0.09 mmol; 2 mg), then EtBr (0.09 mmol; 0.007 mL). After allowing the mixture to warm overnight up to room temperature, the reaction was neutralised with NaHCO3 (1 mL), extracted with ethyl acetate (3*3 mL). Combined organic phases were washed with water (3 mL), dried over MgSO4, concentrated in vacuo to yield the title compound as a brown oil (14 mg; 0.05 mmol; 58%), used as such.

Provenance & Evidence