HCID 59191266, compound → HCID 59191419, compound

HRID 626039Notes

Reaction equation

HRID 626039 reaction equation
FC1C=CC=C(OC2C=CC(CCC)=CC=2OC)N=1.C(C1C=CC(OC2C=CC(N)=C(F)C=2)=C(OC)C=1)C.[CH2:39]([C:41]1[CH:55]=[CH:54][C:44]([O:45][C:46]2[CH:52]=[C:51]([F:53])[CH:50]=[CH:49][C:47]=2[NH2:48])=[C:43]([O:56]C)[CH:42]=1)[CH3:40]>>[NH2:48][C:47]1[CH:49]=[CH:50][C:51]([F:53])=[CH:52][C:46]=1[O:45][C:44]1[CH:54]=[CH:55][C:41]([CH2:39][CH3:40])=[CH:42][C:43]=1[OH:56]

Participants

4

Reactant 3

HCID 59191266HCID 59191266, compoundHCID 59191318HCID 59191318, compoundHCID 59191398HCID 59191398, compound

Product 1

HCID 59191419HCID 59191419, compoundYield 19%

Procedure

According to the procedure of example 5 (b), except substituting 2-fluoro-6-(2-methoxy-4-propylphenoxy)pyridine for a mixture of 4-(4-ethyl-2-methoxyphenoxy)-2-fluoroaniline and 2-(4-ethyl-2-methoxyphenoxy)-4-fluoroaniline (50.9 mg, 0.19 mmol), the title compound (8.9 mg; 19%) was obtained after purification by preparative TLC (dichloromethane/ethyl acetate: 9/1).

Sources & evidence

ORD record
ord-4abe8373a8724f50a418e4b6045ab368
Source dataset
uspto-grants-2016_04
Patent number
US09309179B2

Reaction notes

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