HCID 59191251, compound → HCID 59191336, compound

HRID 626050Notes

Reaction equation

HRID 626050 reaction equation
C(C1C=CC(OC2C=C(F)C=CC=2[N+]([O-])=O)=C(OC)C=1)C.[Br:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]2[CH:35]=[CH:34][C:33]([N+:36]([O-])=O)=[CH:32][C:31]=2[F:39])=[C:25]([O:40][CH3:41])[CH:24]=1>>[Br:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]2[CH:35]=[CH:34][C:33]([NH2:36])=[CH:32][C:31]=2[F:39])=[C:25]([O:40][CH3:41])[CH:24]=1

Participants

3

Reactant 2

HCID 59191251HCID 59191251, compoundHCID 59191273HCID 59191273, compound

Product 1

HCID 59191336HCID 59191336, compoundYield 87.3%

Procedure

According to the procedure of example 50(b) except substituting 4-ethyl-1-(3-fluoro-4-nitrophenoxy)-2-methoxybenzene and 4-ethyl-1-(5-fluoro-2-nitrophenoxy)-2-methoxy benzene for 4-bromo-1-(2-fluoro-4-nitrophenoxy)-2-methoxy benzene (1.88 mmol; 644 mg), the title compound (87%, 512 mg) was obtained as a red oil, and used without further purification.

Sources & evidence

ORD record
ord-a2c92449f7604b98a3148978da2ce1ad
Source dataset
uspto-grants-2016_04
Patent number
US09309179B2

Reaction notes

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