HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Butyn-1-OL → O,N-diBoc-2-(4-amino-2-fluorophenoxy)-5-(3-thienyl ethynyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Butyn-1-OL | HCID 13566 | — |
| Reactant | 3-Ethynylthiophene | HCID 3548422 | — |
| Reactant | O,N,N-triBoc-2-(4-amino-2-fluorophenoxy)-5-bromophenol | HCID 59191361 | — |
| Product | O,N-diBoc-2-(4-amino-2-fluorophenoxy)-5-(3-thienyl ethynyl)phenol | HCID 59191226 | — |
Reaction Steps
According to the procedure of example 11 (a) except substituting 5-bromo-2-(2-methoxy-4-propylphenoxy)pyridine by O,N,N-triBoc-2-(4-amino-2-fluorophenoxy)-5-bromophenol (0.62 mmol; 363 mg) and 3-butyn-1-ol by 3-ethynylthiophene (1.55 mmol; 153 μL), the title compound was obtained as a yellow solid (60%, 195 mg) after purification on silica gel (cyclohexane/ethyl acetate gradient).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309179B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-7385f26e2a134621bf5ed34e3f71f4a6 |
| Source note | uspto-grants-2016_04 |