反应详情

温度

65 °C

To a solution of 3-[4-(2-Benzyloxy-4-ethylphenoxy)-3-fluorophenyl]oxazolidin-2-one (350 mg, 0.85 mmol) in 5 ml of methanol was added barium hydroxide (245 mg, 1.28 mmol) taken in 5 ml of water. The reaction mixture was warmed to 65° C. and stirred overnight (reaction was complete on TLC). The reaction mixture concentrated in vacuo to remove methanol, diluted with water and the aqueous layer was extracted with ethyl acetate. The combined organic fraction was washed with brine, dried over anhydrous Na2SO4 and concentrated to get 300 mg, 91.57% of the title compound as a brown oil, used as such in the next step.

1. custom(reaction was complete on TLC)
2. concentrationThe reaction mixture concentrated in vacuo
3. customto remove methanol
4. additiondiluted with water
5. extractionthe aqueous layer was extracted with ethyl acetate
6. washThe combined organic fraction was washed with brine
7. dry with materialdried over anhydrous Na2SO4
8. concentrationconcentrated