HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → N-Ethyl-4-(4-ethyl-2-hydroxy-phenoxy)-3-fluoro benzene sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | HCID 59191261 | HCID 59191261 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-Ethyl-4-(4-ethyl-2-hydroxy-phenoxy)-3-fluoro benzene sulfonamide | HCID 59191345 | 44% |
Reaction Steps
According to the procedure of example 20 (b) except substituting 4-ethyl-2-methoxy-1-[4-nitro-2-(trifluoromethyl) phenoxy]benzene for 4-(2-Benzyloxy-4-ethyl-phenoxy)-N-ethyl-3-fluoro-benzene sulfonamide (402 mg; 0.94 mmol) and tetrahydrofurane for ethanol (4 mL), the title compound (140 mg; 44%) was obtained as a clear oil, after purification on preparative TLC (dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309179B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-96acc9ab66b14bb489df8e3a85cf17fe |
| Source note | uspto-grants-2016_04 |