HCID 59191221, compound → HCID 59191315, compound

Participants

Reaction Conditions

Reaction Steps

Pd/C (0.02 mmol; 40 mg) was added to a solution of [4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-(3-fluoro-pyridin-4-yl)-methanol (0.19 mmol; 70 mg) in methanol (2 mL) and H2SO4 (0.5 mL). The mixture was flushed twice with hydrogen, and the reaction was stirred overnight at 35° C. The mixture was filtered on celite, washed with methanol. After concentration, water was added (3 mL) and K2CO3 until pH 8. The aqueous phase was extracted with ethyl acetate (2*3 mL). Combined organic phases were dried over MgSO4, concentrated to yield the title compound as a white solid (32 mg; 0.14 mmol; 71%) used as such.

Provenance & Evidence