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A solution of methyl ester 10 (87.2 mg, 0.304 mmol) in dry CH2Cl2 (8 mL) was cooled to −78° C. under argon. DIBAL-H (1M sol. in hexanes, 0.40 mL) was added slowly and the reaction mixture was stirred for 1 h at this temperature. The reaction was quenched by addition of MeOH (100 μL) and the mixture was warmed to rt. A pH 7 phosphate buffer (0.5M solution, 2 mL) was added. The aqueous phase was extracted with CH2Cl2 (3×) and the combined organic phase washed with brine, dried (Na2SO4), filtered, and evaporated in vacuo. The crude aldehyde solution was passed through a short plug of silica gel, initially deactivated with 1% Et3N, using hexanes/EtOAc (5:1) as the eluent. After evaporation, the crude product was directly submitted to the next step. The residue was re-dissolved in dry benzene (degassed, 2 mL) under argon and the solution transferred into a sealable tube. (nBu3Sn)2O (22.5 μL, 26.3 mg, 44 μmol), Ph2SiH2 (42 μL, 41.6 mg, 0.22 mmol), EtOH (45 μL), and AIBN (10 mg) were successively added. The sealed tube was placed with stirring in an oil bath at 80° C. for 6 h. After cooling to room temperature, the reaction mixture was diluted with Et2O (2 mL) and aqueous 0.5M HCl solution (2 mL) was added. After stirring at room temperature for 15 min, the aqueous phase was extracted with Et2O (3×). The combined organic phase was washed with saturated aqueous NaHCO3 solution, brine, dried (MgSO4), filtered, and evaporated. The residue was purified by flash chromatography on silica gel using hexanes/EtOAc (6:1 to 2:1) to afford the (R)-alcohol 11 (50 mg, 64% over 2 steps) as a white solid; 5 mg of the other 3-(S)-diastereoisomer was also isolated and only traces of 1,2 reduction product were observed. TLC: Rf=0.46 (hexanes/EtOAc=3:1); [α]D20+22.3° (c 0.67, CHCl3); 1H NMR (CDCl3, 300 MHz) δ 4.69 (dt, J=3.8, 7.2 Hz, 1H), 4.19-4.02 (m, 3H), 3.72 (d, J=9.8 Hz, 1H), 2.48 (q, J=7.5 Hz, 1H), 2.13-1.96 (m, 2H), 1.70-1.55 (m, 2H), 1.47-1.25 (m, 1H), 0.86 (s, 9H), 0.03 (s, 6H); 13C NMR (CDCl3, 75 MHz) δ 82.2, 78.3, 73.1, 72.7, 50.9, 42.4, 39.0, 25.8, 17.5, −4.8, −4.9.

1. customThe reaction was quenched by addition of MeOH (100 μL)
2. additionA pH 7 phosphate buffer (0.5M solution, 2 mL) was added
3. extractionThe aqueous phase was extracted with CH2Cl2 (3×)
4. washthe combined organic phase washed with brine
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. customevaporated in vacuo
8. customAfter evaporation
9. dissolutionThe residue was re-dissolved in dry benzene (degassed, 2 mL) under argon
10. customthe solution transferred into a sealable tube
11. stirringwith stirring in an oil bath at 80° C. for 6 h
12. temperatureAfter cooling to room temperature
13. additionwas added
14. stirringAfter stirring at room temperature for 15 min
15. extractionthe aqueous phase was extracted with Et2O (3×)
16. washThe combined organic phase was washed with saturated aqueous NaHCO3 solution, brine
17. dry with materialdried (MgSO4)
18. filtrationfiltered
19. customevaporated
20. customThe residue was purified by flash chromatography on silica gel