HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Chlorothiophen-3-yl)propan-1-one → (E)-4-(1-(4-(2-chloroethoxy)phenyl)-2-(5-chlorothiophen-3-yl)-but-1-enyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Chlorothiophen-3-yl)propan-1-one | HCID 70383469 | — |
| Reactant | [4-(2-Chloroethoxy)phenyl](4-hydroxyphenyl)methanone | HCID 89656364 | — |
| Product | (E)-4-(1-(4-(2-chloroethoxy)phenyl)-2-(5-chlorothiophen-3-yl)-but-1-enyl)phenol | HCID 89672888 | 45% |
Reaction Steps
Following general procedure of McMurry reaction as described in example 1, step B, 1-(5-chlorothiophen-3-yl)propan-1-one (1.5 g, 1.0 eq) was reacted with (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone (2.0 g, 1.2 eq) to give 0.8 g desired product (45% yield, E).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-3360b579eda74cbb9ee2440283fdd915 |
| Source note | uspto-grants-2016_04 |