1,2-Dibromoethane → HCID 89656467, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 3-bromo-4-hydroxybenzoate (5.0 g, 1.0 eq) in 20 mL DMF were added BrCH2CH2Br (11 mL, 6.0 eq) and K2CO3 (6.0 g, 2.0 eq). The mixture was heated to 60° C. for 6 h and purified by column chromatography with petroleum ether:EtOAc=3:1 to give the desired product (6.0 g, 80% yield). 1H NMR (400 MHz, CDCl3) δ 8.24 (s, 1H), 7.96 (d, J=8.8 Hz, 1H), 6.90 (d, J=8.8 Hz, 1H), 4.40 (t, J=6.8 Hz, 2H), 3.90 (s, 3H), 3.71 (t, J=6.4 Hz, 2H)

Provenance & Evidence