反应详情

BBr3 (20 mL, 0.211 mol) was added to 3-fluoro-4-methoxybenzonitrile (15.6 g, 0.103 mol) in dichloromethane (100 mL) at 0° C. The mixture was refluxed for 3 days under a nitrogen atmosphere. The reaction mixture was quenched with ice water and extracted with dichloromethane. The organic layer was washed with water and brine and then dried over sodium sulfate. Solvent evaporation under reduced pressure gave 13.3 g (94%) of the product as a gray solid. 1H NMR (400 MHz, CDCl3) δ 7.38-7.42 (m, 2H), 7.09 (dd, J=8.8 Hz, 8.4 Hz, 1H), 5.68 (s, 1H).

1. temperatureThe mixture was refluxed for 3 days under a nitrogen atmosphere
2. customThe reaction mixture was quenched with ice water
3. extractionextracted with dichloromethane
4. washThe organic layer was washed with water and brine
5. dry with materialdried over sodium sulfate
6. customSolvent evaporation under reduced pressure