HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenyl-1-propanone → 4-(1-(4-(2-Bromoethoxy)-3-fluorophenyl)-2-phenylbut-1-enyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenyl-1-propanone | HCID 7148 | — |
| Reactant | (4-(2-Bromoethoxy)-3-fluorophenyl)(4-hydroxyphenyl)methanone | HCID 89656059 | — |
| Product | 4-(1-(4-(2-Bromoethoxy)-3-fluorophenyl)-2-phenylbut-1-enyl)phenol | HCID 121266724 | 99.6% |
Reaction Steps
Following general procedure of McMurry reaction as described in example 1, step B, (4-(2-bromoethoxy)-3-fluorophenyl)(4-hydroxyphenyl)methanone (311 mg, 0.917 mmol) was reacted with propiophenone (246 mg, 1.83 mmol) to give 403 mg desired product (99.6% yield, Z/E=1/1) as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-bb1407722d11477b93b017d0f10e6362 |
| Source note | uspto-grants-2016_04 |