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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62614Generated: October 25, 2026

Sodium Hydroxide → 3-Ethoxybicyclo[1.1.1]pentan-1-amine

https://huagongshe.com/reaction/62614

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantN-{3-ethoxybicyclo[1.1.1]pentan-1-yl}acetamideHCID 86287954—
Product3-Ethoxybicyclo[1.1.1]pentan-1-amineHCID 86288025—

Reaction Steps

Hydrolysis of N-(3-ethoxybicyclo[1.1.1]pentan-1-yl)acetamide (2) with sodium hydroxide (or basic aqueous conditions) gives 3-ethoxybicyclo[1.1.1]pentan-1-amine (6) (Scheme 6).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447026B2
Source datasetuspto-grants-2016_09
ORD IDord-6007781c413e44aa9d3e693afc00a6e8
Source noteuspto-grants-2016_09