1-(3-Fluoro-4-hydroxyphenyl)propan-1-one → 4-(1-(4-(2-Chloroethoxy)phenyl)-1-(4-hydroxyphenyl)but-1-en-2-yl)-2-fluorophenol

Participants

Reaction Steps

Following general procedure of McMurry reaction as described in example 1, step B, 1-(3-fluoro-4-hydroxyphenyl)propan-1-one (255 mg, 1.52 mmol) was reacted with (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone (629 mg, 2.27 mmol) to give 549 mg desired product (88% yield).

Provenance & Evidence