HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenyl-1-propanone → 4-(1-(4-(2-Chloroethoxy)phenyl)-2-phenylbut-1-enyl)-2-fluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenyl-1-propanone | HCID 7148 | — |
| Reactant | (4-(2-Chloroethoxy)phenyl)(3-fluoro-4-hydroxyphenyl)methanone | HCID 89656051 | — |
| Product | 4-(1-(4-(2-Chloroethoxy)phenyl)-2-phenylbut-1-enyl)-2-fluorophenol | HCID 123240423 | — |
Reaction Steps
Following general procedure of McMurry reaction as described in example 1, step B, (4-(2-chloroethoxy)phenyl)(3-fluoro-4-hydroxyphenyl)methanone (350 mg, 1.19 mmol) was reacted with propiophenone (319 mg, 2.38 mmol) to give the desired product (quant.) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-b03ec1d027cc4f6cab9ca746f37f3d73 |
| Source note | uspto-grants-2016_04 |