Hydrogen Peroxide → HCID 89655801, compound

Participants

Reaction Steps

To a solution of (4-(tetrahydro-2H-pyran-2-yloxy)phenyl)(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)methanone (410 mg, 1 mmol) in 20 mL of THF was added 0.5 mL 33% H2O2 and the reaction was stirred for 1 h at rt. The reaction was then quenched with aq. Na2SO3, extracted with EtOAc, washed with water and brine, dried, filtered, concentrated, and purified by column chromatography to give the desired product (240 mg, 80% yield).

Provenance & Evidence