HCID 89656225, compound → HCID 89655848, compound

Participants

Reaction Steps

A flask was charged with (6-(3-(dimethylamino)prop-1-ynyl)pyridin-3-yl)-(4-methoxyphenyl)methanone (294 mg, 1 mmol) and Riney Ni (0.2 eq), and 20 mL methanol. The mixture was stirred under hydrogen at room temperature and atmospheric pressure for 2 h. The catalyst was filtered off through a pad of celite, washed with EtOAc. The filtrate was concentrated under reduced pressure to give the product (284 mg, 95% yield).

Provenance & Evidence