反应详情

Raney nickel (2.4 mg, 0.04 mmol, 10 mol %) was added to a solution of tert-butylmethyl(3-(5-(4-(tetrahydro-2H-pyran-2-yloxy)benzoyl)pyridin-2-yl)prop-2-ynyl)carbamate (180 mg, 0.4 mmol) in 3 mL methanol at room temperature, and the reaction mixture was stirred for 1 h under hydrogen atmosphere. The nickel was filtered off and the filtrate was concentrated in vacuo to afford the desired product as a yellow solid (100 mg, 55.6% yield).

1. filtrationThe nickel was filtered off
2. concentrationthe filtrate was concentrated in vacuo