反应详情

A mixture of N-methoxy-N-methyl-4-oxocyclohexanecarboxamide (2.1 g, 0.114 mol), glycol (0.9 g, 0.136 mol) and toluenesulfonate (0.1 g, cat) in toluene (30 mL) was refluxed overnight and then concentrated. Water was added, and the mixture was extracted with ethyl acetate. The extract was concentrated and purified by silica gel column chromatography (CH2Cl2:MeOH=100:1) to give the desired product (1 g, 38.4% yield).

1. temperaturewas refluxed overnight
2. concentrationconcentrated
3. additionWater was added
4. extractionthe mixture was extracted with ethyl acetate
5. concentrationThe extract was concentrated
6. custompurified by silica gel column chromatography (CH2Cl2:MeOH=100:1)