[4-(2-Chloroethoxy)phenyl](4-hydroxyphenyl)methanone → 4-(1-(4-(2-chloroethoxy)phenyl)-1-(4-hydroxyphenyl)-but-1-en-2-yl)-1-methylpyridin-2(1H)-one

Participants

Reaction Steps

Following general procedure of McMurry reaction as described in example 1, step B, 1-methyl-4-propionylpyridin-2(1H)-one (105 mg, 1.0 eq) was reacted with (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone (352 mg, 2.0 eq) to give the desired product (Z/E=1:1).

Provenance & Evidence