HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-hydroxy-N-methoxy-N-methylpicolinamide → 1-(5-Hydroxypyridin-2-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-hydroxy-N-methoxy-N-methylpicolinamide | HCID 86688981 | — |
| Reactant | HCID 178461630 | HCID 178461630 | — |
| Product | 1-(5-Hydroxypyridin-2-yl)propan-1-one | HCID 112583846 | 48% |
Reaction Steps
Following the same procedure as described in example 11, step B, 5-hydroxy-N-methoxy-N-methylpicolinamide (0.5 g, 1.0 eq) was reacted with EtMgBr (6.0 mL, 4.0 eq) to get the desired product (0.2 g, 48% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-37221bf7b04e4cfd9269c9bcc61f673d |
| Source note | uspto-grants-2016_04 |