HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(2-Chloroethoxy)phenyl](4-hydroxyphenyl)methanone → 6-(1-(4-(2-Chloroethoxy)phenyl)-1-(4-hydroxyphenyl)but-en-2-yl)pyridin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(2-Chloroethoxy)phenyl](4-hydroxyphenyl)methanone | HCID 89656364 | — |
| Reactant | 1-(5-Hydroxypyridin-2-yl)propan-1-one | HCID 112583846 | — |
| Product | 6-(1-(4-(2-Chloroethoxy)phenyl)-1-(4-hydroxyphenyl)but-en-2-yl)pyridin-3-ol | HCID 137146809 | — |
Reaction Steps
Following general procedure of McMurry reaction as described in example 1, step B, 1-(5-hydroxypyridin-2-yl)propan-1-one (0.15 g, 1.0 eq) was reacted with (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone (0.549 g, 2.0 eq) to give the desired product (Z/E=1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-942ed8b2886748848a8baf6839d88361 |
| Source note | uspto-grants-2016_04 |