HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 626215Generated: November 1, 2026
Hydrochloric Acid → 4-Hydroxy-3-nitrobenzoic acid
https://huagongshe.com/reaction/626215
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chloro-3-nitrobenzoic acid | HCID 7320 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Hydroxy-3-nitrobenzoic acid | HCID 12033 | 101.3% |
Reaction Steps
A mixture of 4-chloro-3-nitrobenzoic acid (20 g, 1.0 eq) and NaOH (20.5 g, 2.0 eq) in 100 mL H2O was reflux at 100° C. overnight. After cooling to rt, con. HCl was added to pH=7. The precipitate thus formed was isolated by filtration, washed with cold water, and dried, to give the desired product as a white solid (18.4 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09309211B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-36e9292583794eca85bcb849d80baf79 |
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| Source note | uspto-grants-2016_04 |
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