(6-chloropyridin-3-yl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone → 4-(1-(4-(2-Bromoethoxy)-3-fluorophenyl)-2-phenylbut-1-enyl)phenol

참여 물질

반응 단계

According to general procedure of McMurry reaction as example 1, step D described, (4-(2-bromoethoxy)-3-fluorophenyl)(4-hydroxyphenyl)methanone (150 mg, 0.442 mmol) was reacted with 1-(2,3-dihydrobenzofuran-5-yl)propan-1-one (94 mg, 0.533 mmol, made by example 1, step A) to give 145 mg desired product (68%, Z/E=1/1) as a gray solid.

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