HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(4-Amino-3-nitrophenyl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-(2-nitro-4-propanoylphenyl)acetamide | HCID 59569038 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 1-(4-Amino-3-nitrophenyl)propan-1-one | HCID 89672887 | 90.1% |
Reaction Steps
A solution of N-(2-nitro-4-propionylphenyl)acetamide (3.36 g, 10 mmol) in 30 mL 35% HCl was heated to reflux for 1 h and cooled. The pH was adjusted to 7 by adding aqueous ammonia under stirring. The precipitate was collected by filtration to give the desired product as a yellow solid (1.75 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-ea8c148e812047ff9dc1cf4ef97d453b |
| Source note | uspto-grants-2016_04 |