Methylamine → HCID 71615975, compound

Participants

Reaction Steps

According to the same procedure as example 1, step E described, (E)-4-(1-(4-(2-chloroethoxy)phenyl)-2-(1-methyl-1H-benzo[d]imidazol-5-yl)but-1-enyl)phenol (made by example 8, step F) was reacted with MeNH2 (30% wt in water) in MeOH under reflux to give the desired (E)-product. 1H NMR (400 MHz, CDCl3) δ 7.78 (s, 1H), 7.63 (s, 1H), 7.18 (d, J=8.8 Hz, 2H), 7.13 (d, J=8.4 Hz, 1H), 7.01 (dd, J=8.4 Hz, 1.2 Hz, 1H), 6.88 (d, J=8.8 Hz, 2H), 6.72 (d, J=8.4 Hz, 2H), 6.40 (d, J=8.4 Hz, 2H), 4.10 (t, J=5.2 Hz, 2H), 3.77 (s, 3H), 2.99 (t, J=5.2 Hz, 2H), 2.50-2.55 (m, 5H), 0.91 (t, J=7.2 Hz, 3H); m/z=428[M+1]+.

Provenance & Evidence