HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Benzofuran-5-yl)propan-1-one → 4-(2-(Benzofuran-5-yl)-1-(4-(2-chloroethoxy)phenyl)but-1-enyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Benzofuran-5-yl)propan-1-one | HCID 67336270 | — |
| Reactant | [4-(2-Chloroethoxy)phenyl](4-hydroxyphenyl)methanone | HCID 89656364 | — |
| Product | 4-(2-(Benzofuran-5-yl)-1-(4-(2-chloroethoxy)phenyl)but-1-enyl)phenol | HCID 124018153 | 80% |
Reaction Steps
According to general procedure of McMurry reaction as example 1, step D described, 1-(benzofuran-5-yl)propan-1-one (250 mg, 1.0 eq) was reacted with (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone (794 mg, 2.0 eq) to give 480 mg desired product (80%, Z/E=1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-021c708fe55e43f2be3d221c3245b607 |
| Source note | uspto-grants-2016_04 |