tert-Butyl piperazine-1-carboxylate → 4-(2-(2-Chlorobenzofuran-5-yl)-1-(4-(2-(piperazin-1-yl)ethoxy)phenyl)but-1-enyl)phenol

Participants

Reaction Steps

According to the same procedure as example 1, step E described, 4-(2-(2-chlorobenzofuran-5-yl)-1-(4-(2-chloroethoxy)phenyl)but-1-enyl)phenol (70 mg, 1.0 eq, made by example 11, step D) was reacted with tert-butyl piperazine-1-carboxylate (500 mg) in MeOH (3 mL) under reflux and separated via column chromatography, followed by treatment with 1 mL trifluoroacetic acid in 3 mL CH2Cl2 and then purified by column chromatography to give the desired product (Z/E=1/1) as a white solid. m/z=503[M+1]+.

Provenance & Evidence