N,N'-Dimethylethylenediamine → HCID 72680491, compound

HRID 626269Notes

Reaction equation

HRID 626269 reaction equation
[Cl:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([CH2:27][CH3:28])=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=3)[C:13]3[CH:14]=[N:15][C:16](Cl)=[CH:17][CH:18]=3)=[CH:7][C:5]=2[CH:6]=1.[CH3:29][NH:30][CH2:31][CH2:32][NH:33][CH3:34]>>[Cl:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([CH2:27][CH3:28])=[C:12]([C:20]3[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=3)[C:13]3[CH:14]=[N:15][C:16]([N:30]([CH3:29])[CH2:31][CH2:32][NH:33][CH3:34])=[CH:17][CH:18]=3)=[CH:7][C:5]=2[CH:6]=1

Participants

3

Reactant 2

HCID 8070N,N'-DimethylethylenediamineHCID 121266728HCID 121266728, compound

Product 1

HCID 72680491HCID 72680491, compound

Procedure

According to the same procedure as example 16, step C described, 4-(2-(2-chlorobenzofuran-5-yl)-1-(6-chloropyridin-3-yl)but-1-enyl)phenol (70 mg, 1.0 eq) was reacted with N,N′-dimethylethane-1,2-diamine (150 mg, 10 eq) to give the desired product (Z/E=1/1). m/z=462[M+1]+.

Sources & evidence

ORD record
ord-0f6f9e2472a0492790fa8a47d614aa11
Source dataset
uspto-grants-2016_04
Patent number
US09309211B2

Reaction notes

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