反应详情

N-Phenyl-3-difluoromethyl-5-trifluoromethyl-4-pyrazolecarboxylic acid ethyl ester (3.0 g, 9.0 mmol) in ethanol (15 ml) was admixed gradually with an 8N aqueous sodium hydroxide solution (3.4 ml) and stirred at room temperature for 3 h. The solvent was removed by rotary evaporation; the residue was taken up in water (40 ml) and extracted with diethyl ether (20 ml). Acidification to pH 1 with 6M HCl was followed by extraction with ethyl acetate (3×30 ml). The combined organic phases were dried over sodium sulphate and filtered, and the solvent was removed by rotary evaporation. N-Phenyl-3-difluoromethyl-5-trifluoromethyl-4-pyrazolecarboxylic acid (2.58 g, 8.43 mmol, 94%) was isolated as a colourless solid.

1. customThe solvent was removed by rotary evaporation
2. extractionextracted with diethyl ether (20 ml)
3. extractionAcidification to pH 1 with 6M HCl was followed by extraction with ethyl acetate (3×30 ml)
4. dry with materialThe combined organic phases were dried over sodium sulphate
5. filtrationfiltered
6. customthe solvent was removed by rotary evaporation